## Course Standards

## General Course Information and Notes

### General Notes

Laboratory investigations that include the use of scientific inquiry, research, measurement, problem solving, laboratory apparatus and technologies, experimental procedures, and safety procedures are an integral part of this course. The National Science Teachers Association (NSTA) recommends that at the high school level, all students should be in the science lab or field, collecting data every week. School laboratory investigations (labs) are defined by the National Research Council (NRC) as an experience in the laboratory, classroom, or the field that provides students with opportunities to interact directly with natural phenomena or with data collected by others using tools, materials, data collection techniques, and models (NRC, 2006, p. 3). Laboratory investigations in the high school classroom should help all students develop a growing understanding of the complexity and ambiguity of empirical work, as well as the skills to calibrate and troubleshoot equipment used to make observations. Learners should understand measurement error; and have the skills to aggregate, interpret, and present the resulting data (National Research Council, 2006, p.77; NSTA, 2007). Bioscience II is a rigorous laboratory based course that provides an advanced foundation in the concepts, theories, and pioneering methods involved in micro and molecular based research including medical research, functional genomics, gene discovery, agriculture and forensics. Students will learn how to design plasmids and primers for polymerase chain reactions (PCR). Course focus will be on proteomics (the study of protein expression), protein separation and analysis, protein chromatography purification, protein quantification through spectroscopy, cladistical analysis, immunology, stem cell research, gene sequencing, and bioinformatics using BLAST (Basic Local Alignment Search Tool.) Emphasis will be placed on training students in the means by which to design experiments in preparation for independent research. Students will learn the principles, methodologies, and applications of equipment such as thermocyclers, horizontal and vertical gel electrophoresis, micropipettes, spectrophotometers, centrifuges, and other advanced laboratory apparatus used in the bioscience industry.

Laboratory activities may include but not be limited to:

- The preparation of buffer solutions and polyacrylamide gels for vertical electrophoresis;
- Quantitative analysis of protein molecular weights by developing a standard curve;
- Western blotting and ELISA testing;
- The preparation of serial dilutions for spectroscopy to determine unknown concentrations;
- Bacterial transformation and ligation using bacterial blue/white screening;
- Extraction of DNA for chromatography purification to be used for electrophoresis;
- Polymerase chain reactions using self designed primers;
- Gene Sequencing and Bioinformatics.

** Honors and Advanced Level Course Note: **Advanced courses require a greater demand on students through increased academic rigor. Academic rigor is obtained through the application, analysis, evaluation, and creation of complex ideas that are often abstract and multi-faceted. Students are challenged to think and collaborate critically on the content they are learning. Honors level rigor will be achieved by increasing text complexity through text selection, focus on high-level qualitative measures, and complexity of task. Instruction will be structured to give students a deeper understanding of conceptual themes and organization within and across disciplines. Academic rigor is more than simply assigning to students a greater quantity of work.

**Special Notes Instructional Practices: **Teaching from a range of complex text is optimized when teachers in all subject areas implement the following strategies on a routine basis:

- Ensuring wide reading from complex text that varies in length.
- Making close reading and rereading of texts central to lessons.
- Emphasizing text-specific complex questions, and cognitively complex tasks, reinforce focus on the text and cultivate independence.
- Emphasizing students supporting answers based upon evidence from the text.
- Providing extensive research and writing opportunities (claims and evidence).

Prerequisite: Honors Chemistry and Bioscience I/or AP Biology

Corequisite: Honors Physics

**Science and Engineering Practices** (NRC *Framework for K-12 Science Education, 2010*)

- Asking questions (for science) and defining problems (for engineering).
- Developing and using models.
- Planning and carrying out investigations.
- Analyzing and interpreting data.
- Using mathematics, information and computer technology, and computational thinking.
- Constructing explanations (for science) and designing solutions (for engineering).
- Engaging in argument from evidence.
- Obtaining, evaluating, and communicating information.

** Literacy Standards in Science**

Secondary science courses include reading standards for literacy in science and technical subjects 6-12 and writing standards for literacy in history/social studies, science, and technical subjects 6-12. The courses also include speaking and listening standards. For a complete list of standards required for this course click on the blue tile labeled course standards. You may also download the complete course including all required standards and notes sections using the export function located at the top of this page.

**English Language Development ELD Standards Special Notes Section:**

Teachers are required to provide listening, speaking, reading and writing instruction that allows English language learners (ELL) to communicate information, ideas and concepts for academic success in the content area of Science. For the given level of English language proficiency and with visual, graphic, or interactive support, students will interact with grade level words, expressions, sentences and discourse to process or produce language necessary for academic success The ELD standard should specify a relevant content area concept or topic of study chosen by curriculum developers and teachers which maximizes an ELL's need for communication and social skills. To access an ELL supporting document which delineates performance definitions and descriptors, please click on the following link: http://www.cpalms.org/uploads/docs/standards/eld/SC.pdf

### General Information

**Course Number:**2000510

**Course Path:**

**Abbreviated Title:**BIOSCIENCE 2 HON

**Number of Credits:**One (1) credit

**Course Length:**Year (Y)

**Course Attributes:**

- Honors

**Course Type:**Core Academic Course

**Course Level:**3

**Course Status:**Course Approved

**Grade Level(s):**9,10,11,12

**Graduation Requirement:**Equally Rigorous Science

## Educator Certifications

## Student Resources

## Original Student Tutorials

Learn how scientists measure viral spread and use this information to make recommendations for the public in this interactive tutorial.

Type: Original Student Tutorial

Learn how to identify different sources of scientific claims and to evaluate their reliability in this interactive tutorial.

Type: Original Student Tutorial

Learn how to test scientific claims and judge competing hypotheses by understanding how they can be tested against one another in this interactive tutorial.

Type: Original Student Tutorial

Genetic mutations can cause illness. Learn how genetic diseases can affect you and your communities in this interactive tutorial.

Type: Original Student Tutorial

Dive into genetic mutations and learn how they can alter the phenotypes of organisms.

Type: Original Student Tutorial

Explores how vaccines and antibiotics provide an extra level of protection from infectious agents and pathogens.

Type: Original Student Tutorial

Learn how the expression of genes is affected our environment, including lifestyle choices. In this interactive tutorial, you'll also explore how a combination of genes and environmental factors can impact the risk of multifactorial disease.

Type: Original Student Tutorial

Pathogens of all sorts can make us sick. Learn the whats, whys, and hows of the process in this interactive tutorial.

Type: Original Student Tutorial

Examine the hallowed words of Abraham Lincoln's "Gettysburg Address." In this interactive tutorial you'll identify his point of view, reasoning, and evidence in order to evaluate his effectiveness as a speaker.

Type: Original Student Tutorial

Learn to distinguish between public health issues and individual health issues in this interactive tutorial.

This is part 1 of 4 in a series of tutorials addressing this standard.

Type: Original Student Tutorial

See how data are interpreted to better understand the reproductive strategies taken by sea anemones with this interactive tutorial.

Type: Original Student Tutorial

Examine field sampling strategies used to gather data and avoid bias in ecology research. This interactive tutorial features the CPALMS Perspectives video Sampling Strategies for Ecology Research in the Intertidal Zone*.*

Type: Original Student Tutorial

Learn about the first step of protein synthesis, transcription of DNA to RNA. In this interactive tutorial, you'll explore epigenetics as a mechanism to activate or inactivate gene expression.

Type: Original Student Tutorial

Explore the basic processes of transcription and translation, and how they result in the expression of genes as you complete this interactive tutorial.

Type: Original Student Tutorial

Learn how to identify and describe the leading scientific explanations of the origin of life on Earth.

Type: Original Student Tutorial

Learn what scientific laws and scientific theories are and how they are different from what we commonly call laws and theories outside of science with this interactive tutorial.

Type: Original Student Tutorial

The graph of a quadratic equation is called a parabola [puh-ra-bow-luh]. The key features we will focus on in this tutorial are the vertex (a maximum or minimum extreme) and the direction of its opening. You will learn how to examine a quadratic equation written in vertex form in order to distinguish each of these key features.

Type: Original Student Tutorial

Learn how to identify explicit evidence and understand implicit meaning in a text and demonstrate how and why scientific inferences are drawn from scientific observation and be able to identify examples in biology.

Type: Original Student Tutorial

Learn that a scientific theory is the culmination of many experiments and supplies the most powerful explanation that scientists have to offer with this interactive tutorial.

Type: Original Student Tutorial

Learn how to define what science is and what it is not. In this interactive tutorial, you will identify why certain ways of exploring the universe can and cannot be considered scientific practices.

Type: Original Student Tutorial

Learn to distinguish between questions that can be answered by science and questions that science cannot answer. This interactive tutorial will help you distinguish between science and other ways of knowing, including art, religion, and philosophy.

Type: Original Student Tutorial

Learn how to better understand the composition of DNA, the purpose of the information in DNA, why the DNA sequence is considered a universal code, and what might happen if mistakes appear in the code.

Type: Original Student Tutorial

Learn how to identify and define types of biotechnology and consider the impacts of biotechnologies on the individual, society and the environment in this interactive tutorial.

Type: Original Student Tutorial

Learn how to identify the basic functions of the immune system. You will also be able to distinguish between nonspecific and specific immune responses.

Type: Original Student Tutorial

Explore green chemistry and what it means to be benign by design in this interactive tutorial.

Type: Original Student Tutorial

## Educational Games

Students attempt to save towns from damage prior to the arrival of several different natural disasters. Students will learn the importance of early prevention and actions to protect others, themselves and their property when faced with a natural disaster. Certain disasters are more appropriate for particular grade levels. Each scenario takes between 20 and 45 minutes to play, depending on the disaster for which your students are trying to prepare. There are five scenarios available, hurricane, tsunami, flood, earthquake, and wildfire. Each scenario can be played on easy, medium or hard difficulty levels. As with life, there are no "perfect solutions" to each scenario and no "perfect score", so students can play multiple times and the scenarios will still be slightly different.These simulation are part of a larger website that provides multiple links for natural disasters.

Type: Educational Game

Type: Educational Game

## Lesson Plans

This BLOSSOMS lesson discusses Carbon Dioxide, and its impact on climate change. The main learning objective is for students to become more familiar with human production of Carbon Dioxide gas, as well as to gain an awareness of the potential for this gas to effect the temperature of Earth’s atmosphere. This lesson should take about an hour to complete. In order to complete the lesson, the teacher will need: printed copies of signs representing the different products and processes that take place in the carbon cycle (included), samples of matter that represent those products, handouts for the students to create a graphic of the carbon cycle (included) and graph paper or graphing software for students to create graphs. In the breaks of this BLOSSOMS lesson, students will be creating models of the carbon cycle as well as observing experiments and analyzing data from them. It is hoped that this lesson will familiarize students with ways in which carbon moves through our environment and provide them with some personal connection to the impact that an increased concentration of CO_{2} can have on air temperature. The goal is to spark their interest and hopefully to encourage them to ask and investigate more questions about the climate.

Type: Lesson Plan

Learning objectives: Students will learn what DNA fingerprinting is, what it is used for, and how it is used in paternity testing and forensics. Students will see how this technique actually works in lab. Students will learn how to analyze the gels used in this technique to match babies to parents, and crime scene evidence to suspects.

Type: Lesson Plan

## Perspectives Video: Experts

Jump to it and learn more about how quadratic equations are used in robot navigation problem solving!

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

The tide is high! How can we statistically prove there is a relationship between the tides on the Gulf Coast and in a fresh water spring 20 miles from each other?

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

Statistical analysis played an essential role in using microgravity sensors to determine location of caves in Wakulla County.

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

A cell has made a protein; now what? Learn more about protein secretion!

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

Advances in "big data" are leading to rapid developments in personalized medicine. Learn more!

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

Check this out and learn about how prokaryotes and eukaryotes regulate gene expression.

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

How do you know what genes are thinking? By their expression. Learn more from a plant geneticist.

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

Keep an eye on pH as you learn about what makes acids and bases.

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

Mutations don't just happen to comic book heroes and villains. Learn more about this natural biological phenomenon!

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

Don't get twisted in a knot about proteins; learn about their structure!

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

What's in a molecular biologist's toolbox? Very small tools for working with cellular machines and molecules!

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

Humans aren't the only ones who get their fingerprints taken. Learn how this scientist is like a crime scene investigator using oil "fingerprints" to explain the orgins of spilled oil.

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

A viticulture scientist explains grape expectations for medicine and society.

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Expert

## Perspectives Video: Professional/Enthusiasts

Listen in as a computing enthusiast describes how hexadecimal notation is used to express big numbers in just a little space.

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Professional/Enthusiast

Get fired up as you learn more about ceramic glaze recipes and mathematical units.

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Professional/Enthusiast

Landfills have a come a long way! Explore modern techniques for managing our environmental impact through responsible waste disposal.

Download the CPALMS Perspectives video student note taking guide.

Type: Perspectives Video: Professional/Enthusiast

## Presentation/Slideshows

It is often difficult, sometimes impossible, to get a definitive answer to some of life's most enduring questions. Scientific processes provide alternative explanations for a wide variety of phenomena by piecing together all the available information. This interactive activity on the *Evolution* website explores four possible hypotheses to explain what caused the extinction of the dinosaurs 65 million years ago, inviting the viewer to consider the evidence and come to their own decision.

Type: Presentation/Slideshow

A PowerPoint with speaker notes covering infectious diseases, causes, transmission, and control.

Type: Presentation/Slideshow

## Problem-Solving Tasks

Students explore the structure of the operation *s*/(v*n*). This question provides students with an opportunity to see expressions as constructed out of a sequence of operations: first taking the square root of *n*, then dividing the result of that operation into *s*.

Type: Problem-Solving Task

The purpose of this task is to allow students to demonstrate an ability to construct boxplots and to use boxplots as the basis for comparing distributions.

Type: Problem-Solving Task

This problem could be used as an introductory lesson to introduce group comparisons and to engage students in a question they may find amusing and interesting.

Type: Problem-Solving Task

This problem solving task asks students to examine the relationship between shops and crimes by using a correlation coefficient.

Type: Problem-Solving Task

The task provides a context to calculate discrete probabilities and represent them on a bar graph.

Type: Problem-Solving Task

In this example, students are asked to write a function describing the population growth of algae. It is implied that this is exponential growth.

Type: Problem-Solving Task

In this task, students use trigonometric functions to model the movement of a point around a wheel and, through space. Students also interpret features of graphs in terms of the given real-world context.

Type: Problem-Solving Task

This problem solving task challenges students to find the linear, exponential and quadratic functions based on two points.

Type: Problem-Solving Task

This problem solving task asks students to predict and model US population based on a chart of US population data from 1982 to 1988.

Type: Problem-Solving Task

This problem solving task asks students to solve five exponential and linear function problems based on a US population chart for the years 1790-1860.

Type: Problem-Solving Task

The purpose of this task is to give students an opportunity to explore various aspects of exponential models (e.g., distinguishing between constant absolute growth and constant relative growth, solving equations using logarithms, applying compound interest formulas) in the context of a real world problem with ties to developing financial literacy skills. In particular, students are introduced to the idea of inflation of prices of a single commodity, and are given a very brief introduction to the notion of the Consumer Price Index for measuring inflation of a body of goods.

Type: Problem-Solving Task

This task gives a variation of real-life contexts which could be modeled by a linear or exponential function. The key distinguishing feature between the two is whether the change by equal factors over equal intervals (exponential functions), or by a constant increase per unit interval (linear functions). The task could either be used as an assessment problem on this distinction, or used as an introduction to the differences between these very important classes of functions.

Type: Problem-Solving Task

This task requires students to use the fact that on the graph of the linear function h(x) = ax + b, the y-coordinate increases by a when x increases by one. Specific values for a and b were left out intentionally to encourage students to use the above fact as opposed to computing the point of intersection, (p,q), and then computing respective function values to answer the question.

Type: Problem-Solving Task

This task gives students an opportunity to work with exponential functions in a real world context involving continuously compounded interest. They will study how the base of the exponential function impacts its growth rate and use logarithms to solve exponential equations.

Type: Problem-Solving Task

This exploratory task requires the student to use properties of exponential functions in order to estimate how much Carbon 14 remains in a preserved plant after different amounts of time.

Type: Problem-Solving Task

This task involves a fairly straightforward decaying exponential. Filling out the table and developing the general formula is complicated only by the need to work with a fraction that requires decisions about rounding and precision.

Type: Problem-Solving Task

This task requires students to use the fact that the value of an exponential function f(x) = a · b^x increases by a multiplicative factor of b when x increases by one. It intentionally omits specific values for c and d in order to encourage students to use this fact instead of computing the point of intersection, (p,q), and then computing function values to answer the question.

Type: Problem-Solving Task

This problem assumes that students are familiar with the notation x_{0} and Δx. However, the language "successive quotient" may be new.

Type: Problem-Solving Task

This task assumes that students are familiar with the ?x and ?y notations. Students most likely developed this familiarity in their work with slope.

Type: Problem-Solving Task

An important property of linear functions is that they grow by equal differences over equal intervals. In F.LE Equal Differences over Equal Intervals 1, students prove this for equal intervals of length one unit, and note that in this case the equal differences have the same value as the slope.

Type: Problem-Solving Task

This problem-solving task asks students to examine if linear modeling would be appropriate to describe and predict population growth from select years.

Type: Problem-Solving Task

This problem-solving task provides students an opportunity to experiment with modeling real data by using population growth rates from the past two centuries.

Type: Problem-Solving Task

This problem-solving task challenges students to write expressions and create a table to calculate how much money can be gained after investing at different banks with different interest rates.

Type: Problem-Solving Task

This problem-solving task asks students to describe exponential growth through a real-world problem involving the illegal introduction of fish into a lake.

Type: Problem-Solving Task

This problem-solving emphasizes the expectation that students know linear functions grow by constant differences over equal intervals and exponential functions grow by constant factors over equal intervals.

Type: Problem-Solving Task

This problem-solving task challenges students to find all quadratic functions described by given equation and coordinates, and describe how the graphs of those functions are related to one another.

Type: Problem-Solving Task

This task is meant to be a straight-forward assessment task of graph reading and interpreting skills. This task helps reinforce the idea that when a variable represents time, t = 0 is chosen as an arbitrary point in time and positive times are interpreted as times that happen after that.

Type: Problem-Solving Task

This task could be used for assessment or for practice. It allows students to compare characteristics of two quadratic functions that are each represented differently, one as the graph of a quadratic function and one written out algebraically. Specifically, students are asked to determine which function has the greatest maximum and the greatest non-negative root.

Type: Problem-Solving Task

This task asks students to find the average, write an equation, find the domain, and create a graph of the cost of producing DVDs.

Type: Problem-Solving Task

The principal purpose of the task is to explore a real-world application problem with algebra, working with units and maintaining reasonable levels of accuracy throughout. Students are asked to determine which product will be the most economical to meet the requirements given in the problem.

Type: Problem-Solving Task

In this task students are given graphs of quantities related to weather. The purpose of the task is to show that graphs are more than a collection of coordinate points; they can tell a story about the variables that are involved, and together they can paint a very complete picture of a situation, in this case the weather. Features in one graph, like maximum and minimum points, correspond to features in another graph. For example, on a rainy day, the solar radiation is very low, and the cumulative rainfall graph is increasing with a large slope.

Type: Problem-Solving Task

This problem introduces a logistic growth model in the concrete settings of estimating the population of the U.S. The model gives a surprisingly accurate estimate and this should be contrasted with linear and exponential models.

Type: Problem-Solving Task

This task is for instructional purposes only and students should already be familiar with some specific examples of logistic growth functions. The goal of this task is to have students appreciate how different constants influence the shape of a graph.

Type: Problem-Solving Task

This task can be used as a quick assessment to see if students can make sense of a graph in the context of a real world situation. Students also have to pay attention to the scale on the vertical axis to find the correct match. The first and third graphs look very similar at first glance, but the function values are very different since the scales on the vertical axes are very different. The task could also be used to generate a group discussion on interpreting functions given by graphs.

Type: Problem-Solving Task

In this task, students will use inverse operations to solve the equations for the unknown variable or for the designated variable if there is more than one.

Type: Problem-Solving Task

The purpose of this task is to illustrate through an absurd example the fact that in real life quantities are reported to a certain level of accuracy, and it does not make sense to treat them as having greater accuracy.

Type: Problem-Solving Task

This task operates at two levels. In part it is a simple exploration of the relationship between speed, distance, and time. Part (c) requires understanding of the idea of average speed, and gives an opportunity to address the common confusion between average speed and the average of the speeds for the two segments of the trip.

At a higher level, the task addresses MAFS.912.N-Q.1.3, since realistically neither the car nor the bus is going to travel at exactly the same speed from beginning to end of each segment; there is time traveling through traffic in cities, and even on the autobahn the speed is not constant. Thus students must make judgments about the level of accuracy with which to report the result.

Type: Problem-Solving Task

This task examines, from a mathematical and statistical point of view, how scientists measure the age of organic materials by measuring the ratio of Carbon 14 to Carbon 12. The focus here is on the statistical nature of such dating.

Type: Problem-Solving Task

This task examines, from a mathematical and statistical point of view, how scientists measure the age of organic materials by measuring the ratio of Carbon 14 to Carbon 12. The focus here is on the statistical nature of such dating.

Type: Problem-Solving Task

The problem requires students to not only convert miles to kilometers and gallons to liters but they also have to deal with the added complication of finding the reciprocal at some point.

Type: Problem-Solving Task

This task asks students to calculate the cost of materials to make a penny, utilizing rates of grams of copper.

Type: Problem-Solving Task

Students are asked to use units to determine if the given statement is valid.

Type: Problem-Solving Task

This is a challenging task, suitable for extended work, and reaching into a deep understanding of units. Students are given a scenario and asked to determine the number of people required to complete the amount of work in the time described. The task requires students to exhibit MAFS.K12.MP.1.1, Make sense of problems and persevere in solving them. An algebraic solution is possible but complicated; a numerical solution is both simpler and more sophisticated, requiring skilled use of units and quantitative reasoning. Thus the task aligns with either MAFS.912.A-CED.1.1 or MAFS.912.N-Q.1.1, depending on the approach.

Type: Problem-Solving Task

Students explore and manipulate expressions based on the following statement:

A function f defined for -a < x < a is even if f(-x)=f(x) and is odd if f(-x)=-f(x) when -a < x < a. In this task we assume f is defined on such an interval, which might be the full real line (i.e., a=8).

Type: Problem-Solving Task

Students compare graphs of different quadratic functions, then produce equations of their own to satisfy given conditions.

This exploration can be done in class near the beginning of a unit on graphing parabolas. Students need to be familiar with intercepts, and need to know what the vertex is. It is effective after students have graphed parabolas in vertex form (y=a(x–h)^{2}+k), but have not yet explored graphing other forms.

Type: Problem-Solving Task

Students are asked to interpret the effect on the value of an expression given a change in value of one of the variables.

Type: Problem-Solving Task

Students examine and answer questions related to a scenario similar to a "mixture" problem involving two different mixtures of fertilizer. In this example, students determine and then compare expressions that correspond to concentrations of various mixtures. Ultimately, students generalize the problem and verify conclusions using algebraic rather than numerical expressions.

Type: Problem-Solving Task

Students are asked to interpret expressions and equations within the context of the amounts of caramels and truffles in a box of candy.

Type: Problem-Solving Task

This problem asks students to consider algebraic expressions calculating the number of floor tiles in given patterns. The purpose of this task is to give students practice in reading, analyzing, and constructing algebraic expressions, attending to the relationship between the form of an expression and the context from which it arises. The context here is intentionally thin; the point is not to provide a practical application to kitchen floors, but to give a framework that imbues the expressions with an external meaning.

Type: Problem-Solving Task

This resource describes a simple scenario which can be represented by the use of variables. Students are asked to examine several variable expressions, interpret their meaning, and describe what quantities they each represent in the given context.

Type: Problem-Solving Task

This resource poses the question, "how many vehicles might be involved in a traffic jam 12 miles long?"

This task, while involving relatively simple arithmetic, promps students to practice modeling (MP4), work with units and conversion (N-Q.1), and develop a new unit (N-Q.2). Students will also consider the appropriate level of accuracy to use in their conclusions (N-Q.3).

Type: Problem-Solving Task

In this task students interpret the relative size of variable expressions involving two variables in the context of a real world situation. All given expressions can be interpreted as quantities that one might study when looking at two animal populations.

Type: Problem-Solving Task

The purpose of this task is to identify the structure in the two algebraic expressions by interpreting them in terms of a geometric context. Students will have likely seen this type of process before, so the principal source of challenge in this task is to encourage a multitude and variety of approaches, both in terms of the geometric argument and in terms of the algebraic manipulation.

Type: Problem-Solving Task

The task is a modeling problem which ties in to financial decisions faced routinely by businesses, namely the balance between maintaining inventory and raising short-term capital for investment or re-investment in developing the business.

Type: Problem-Solving Task

This task provides students the opportunity to make use of units to find the gas needed (MAFS.912.N-Q.1.1). It also requires them to make some sensible approximations (e.g., 2.92 gallons is not a good answer to part (a)) and to recognize that Felicia's situation requires her to round up. Various answers to (a) are possible, depending on how much students think is a safe amount for Felicia to have left in the tank when she arrives at the gas station. The key point is for them to explain their choices. This task provides an opportunity for students to practice MAFS.K12.MP.2.1: Reason abstractly and quantitatively, and MAFS.K12.MP.3.1: Construct viable arguments and critique the reasoning of others.

Type: Problem-Solving Task

This task requires students to recognize the graphs of different (positive) powers of x.

Type: Problem-Solving Task

The primary purpose of this task is to lead students to a numerical and graphical understanding of the behavior of a rational function near a vertical asymptote, in terms of the expression defining the function.

Type: Problem-Solving Task

The purpose of this task is to give students practice constructing functions that represent a quantity of interest in a context, and then interpreting features of the function in the light of the context. It can be used as either an assessment or a teaching task.

Type: Problem-Solving Task

This problem involves the meaning of numbers found on labels. When the level of accuracy is not given we need to make assumptions based on how the information is reported. An unexpected surprise awaits in this case, however, as no reasonable interpretation of the level of accuracy makes sense of the information reported on the bottles in parts (b) and (c). Either a miscalculation has been made or the numbers have been rounded in a very odd way.

Type: Problem-Solving Task

## Tutorials

You will learn how the parent function for a quadratic function is affected when f(x) = x^{2}.

Type: Tutorial

This tutorial will help the students to identify the vertex of a parabola from the equation, and then graph the parabola.

Type: Tutorial

This tutorial will help the learners to graph the equation of the quadratic function using the coordinates of the vertex of a parabola adn its x- intercepts.

Type: Tutorial

This tutorial will help you to learn about the exponential functions by graphing various equations representing exponential growth and decay.

Type: Tutorial

A vaccine allows a person to develop acquired immunity against an illness without actually getting the disease. This interactive tutorial will help the learners to understand the process by which vaccines work in the human body.

Type: Tutorial

This Khan Academy video reviews the basic processes of DNA replication and protein synthesis. It then goes on to explain how the terms chromosome, chromatin, and chromatid, relate to each other.

Type: Tutorial

This Khan Academy video describes what happens to a zygote as it becomes an embyro. It further explains what a stem cell is and discusses why there are questions concerning the use of stem cells.

Type: Tutorial

This Khan Academy video explains how variation can be introduced into a species and the importance of sexual reproduction in this process.

Type: Tutorial

This Khan Academy video explains how cytotoxic t cells get activated by MHC-I antigen complexes and then proceed to kill infected cells. This video addresses the concept at a high level of complexity.

Type: Tutorial

This Khan Academy video discusses helper t cells in the immune system. The role of helper t cells in activating b cells is detailed. This challenging tutorial addresses the concept at a high level of complexity.

Type: Tutorial

This Khan Academy video briefly describes DNA replication and then goes into a thorough explanation of both transcription and translation.

Type: Tutorial

This Khan Academy video describes the structure of the molecule DNA in great detail. It also discuses the role DNA plays in the process of protein synthesis, explaining transcription and translation. The video discusses the relationship between DNA and chromosomes as well.

Type: Tutorial

This Khan Academy video describes B lymphocyte cells, and how they are activated and produce antibodies within the immune system.

Type: Tutorial

This Khan Academy video describes non specific immunity, and the specific role of phagocytes. The tutorial explains how phagocytes engulf pathogens that enter the body as a line of defense.

Type: Tutorial

This Khan Academy video contains an overview of the types of immune responses in the body. The differences between humoral adaptive immunity and cell mediated immunity are discussed in detail.

Type: Tutorial

Gene transcription is controlled by multiple factors. Some proteins bind to DNA sequences and start the process of gene transcription. RNA synthesis can only occur when these activators are bound to specific DNA sequences. This tutorial will help you to understand the process of gene transcription.

Type: Tutorial

You will see how the genetic code, using the DNA alphabet A,T,C, and G, produces codons to specify the 20 known amino acids. Each codon consists of a three letter code producing 64 possible words which specify the amino acids and stop signals.

Type: Tutorial

This tutorial will help students understand how the immune system of vertebrates is characterized by acquired responses that are highly specific to particular antigens. This system has the advantage of having a cellular memory for previous infections.

Type: Tutorial

This tutorial will help you to understand the procedure of amplifying a single copy of DNA into millions of copies. Polymerase chain reaction is a molecular prototyping technique which helps in copying small segments of DNA into significant amounts required for molecular and genetic analyses.

Type: Tutorial

This tutorial will help you to understand how allergies develop. Allergies are exaggerated immune responses caused by B cells producing excess IgE antibodies. An allergen (food, dust) is a foreign substance, which binds to the antibodies and triggers a reaction that includes the production of histamine.

This challenging tutorial addresses the concept at a very high level of complexity.

Type: Tutorial

One of the functions of the T-Cells in the immune system is to attack and destroy infected cells. Target cells are cells that have been attacked by a virus. When the target cells have been taken over by a virus and they do not have a good chance of surviving, they trigger their own death. This action reduces the chance that other nearby cells will become infected.

This challenging tutorial addresses the concept at a high level of complexity.

Type: Tutorial

This tutorial will help you to understand the function of phagocytes. Phagocytes are specialized cells that ingest and break down foreign material including bacteria and viruses.

This challenging tutorial addresses the concept at a high level of complexity.

Type: Tutorial

T-cells perform a wide variety of functions in the immune system. In this tutorial you will understand the structure and function of the T-cells.

Type: Tutorial

This tutorial will help you to visualize how DNA fingerprinting uses the pattern of DNA fragments caused by specific enzymes to identify individual organisms including humans, animals, plants or any other organism with DNA.

Type: Tutorial

This tutorial is a full lesson on the process of protein synthesis. Transcription and translation are both explained in detail.

Type: Tutorial

This tutorial will help the student understand about viruses which are small infectious agents that replicate only inside the living cells of other organisms.

Type: Tutorial

This tutorial introduces the polymerase chain reaction (PCR), which is a technique used in molecular biology to make multiple copies of a gene even when only small amounts of DNA are available.

Type: Tutorial

Every day, we are bombarded by attention grabbing headlines that promise miracle cures to all of our ailments -- often backed up by a "scientific study." But what are these studies, and how do we know if they are reliable? David H. Schwartz dissects two types of studies that scientists use, illuminating why you should always approach the claims with a critical eye.

Type: Tutorial

All living things are made of cells. In the human body, these highly efficient units are protected by layer upon layer of defense against icky invaders like the cold virus. Shannon Stiles takes a journey into the cell, introducing the microscopic arsenal of weapons and warriors that play a role in the battle for your health.

Type: Tutorial

This short video describes the process of antibiotic resistance. Right now, you are inhabited by trillions of micro organisms. Many of these bacteria are harmless (or even helpful!), but there are a few strains of ‘super bacteria' that are pretty nasty -- and they're growing resistant to our antibiotics. Why is this happening? Kevin Wu details the evolution of this problem that presents a big challenge for the future of medicine.

Type: Tutorial

This tutorial uses animation and practice opportunities to explore how mutations in DNA can impact the expression of a gene. Get a close up view of the nucleus of a fertilized egg and observe how mutations in different locations of a DNA strand influence the traits that are expressed during development.

Type: Tutorial

This tutorial will demonstrates the process of RNA translation through an interactive animation.

Type: Tutorial

This tutorial will help the learners to review the formation and 3D structures of amino acids with proteins.

Type: Tutorial

This resource explores the electromagnetic spectrum and waves by allowing the learner to observe the refraction of light as it passes from one medium to another, study the relation between refraction of light and the refractive index of the medium, select from a list of materials with different refractive indicecs, and change the light beam from white to monochromatic and observe the difference.

Type: Tutorial

- Observe how the eye's muscles change the shape of the lens in accordance with the distance to the object being viewed
- Indicate the parts of the eye that are responsible for vision
- View how images are formed in the eye

Type: Tutorial

- Learn how a concave spherical mirror generates an image
- Observe how the size and position of the image changes with the object distance from the mirror
- Learn the difference between a real image and a virtual image
- Learn some applications of concave mirrors

Type: Tutorial

- Learn how a convex mirror forms the image of an object
- Understand why convex mirrors form small virtual images
- Observe the change in size and position of the image with the change in object's distance from the mirror
- Learn some practical applications of convex mirrors

Type: Tutorial

- Observe the change of color of a black body radiator upon changes in temperature
- Understand that at 0 Kelvin or Absolute Zero there is no molecular motion

Type: Tutorial

This resource explains how a solar cell converts light energy into electrical energy. The user will also learn about the different components of the solar cell and observe the relationship between photon intensity and the amount of electrical energy produced.

Type: Tutorial

- Observe that light is composed of oscillating electric and magnetic waves
- Explore the propagation of an electromagnetic wave through its electric and magnetic field vectors
- Observe the difference in propagation of light of different wavelengths

Type: Tutorial

- Explore the relationship between wavelength, frequency, amplitude and energy of an electromagnetic wave
- Compare the characteristics of waves of different wavelengths

Type: Tutorial

- Learn to trace the path of propagating light waves using geometrical optics
- Observe the effect of changing parameters such as focal length, object dimensions and position on image properties
- Learn the equations used in determining the size and locations of images formed by thin lenses

Type: Tutorial

## Video/Audio/Animations

With an often unexpected outcome from a simple experiment, students can discover the factors that cause and influence thermohaline circulation in our oceans. In two 45-minute class periods, students complete activities where they observe the melting of ice cubes in saltwater and freshwater, using basic materials: clear plastic cups, ice cubes, water, salt, food coloring, and thermometers. There are no prerequisites for this lesson but it is helpful if students are familiar with the concepts of density and buoyancy as well as the salinity of seawater. It is also helpful if students understand that dissolving salt in water will lower the freezing point of water. There are additional follow up investigations that help students appreciate and understand the importance of the ocean's influence on Earth's climate.

Type: Video/Audio/Animation

Literal equations are formulas for calculating the value of one unknown quantity from one or more known quantities. Variables in the formula are replaced by the actual or 'literal' values corresponding to a specific instance of the relationship.

Type: Video/Audio/Animation

This video presentation will help you to understand how HIV infects a cell and replicates itself using reverse transcriptase and the host's cellular machinery.

Type: Video/Audio/Animation

Ocean explorer Robert Ballard gives a TED Talk relating to the mysteries of the ocean, and the importance of its continued exploration.

Type: Video/Audio/Animation

- Interviews with expert scientists about the genome and mutant organisms
- Examples on model organisms used in genome research
- Animation explaining how mutations occur

Type: Video/Audio/Animation

- This activity provides a historical background about research related to bacterial analysis
- Contains an animation that shows how enzymes work on cutting DNA strands

Type: Video/Audio/Animation

This video takes a look at rearranging a formula to highlight a quantity of interest.

Type: Video/Audio/Animation

- Background on tracking human ancestry using the alu marker
- Animation on polymerase chain reaction, PCR
- Interactive activity for performing PCR

Type: Video/Audio/Animation

Paul Anderson explains the structure and importance of proteins. He describes how proteins are created from amino acids connected by dehydration synthesis. He shows the importance of chemical properties in the R-groups of individual amino acids in the polypeptide.

Type: Video/Audio/Animation

Khan Academy video tutorial on graphing linear equations: "Algebra: Graphing Lines 1"

Type: Video/Audio/Animation

Khan Academy tutorial video that demonstrates with real-world data the use of Excel spreadsheet to fit a line to data and make predictions using that line.

Type: Video/Audio/Animation

This video examines the vocabulary essential for understanding the nature of science and evolution and illustrates how evolution is a powerful, well-supported scientific explanation for the relatedness of all life. A clear definition and description of scientific theory is given.

Type: Video/Audio/Animation

This video discusses how bacteria spread and the pros and cons of bacteria.

Type: Video/Audio/Animation

In this National Science Foundation video and reading selection lab ecologist Janis Dickinson explains how she depends on citizen scientists to help her track the effects of disease, land-use change and environmental contaminants on the nesting success of birds.

Type: Video/Audio/Animation

This site has fantastic short Flash animations of intricate cell processes, including photosynthesis and the electron transport chain.

Type: Video/Audio/Animation

This is a lesson about phenotypical variation within populations and how these differences are essential for biological evolution. Students will use a model organism (in this case, kidney beans) to explore variation patterns and subsequently connect these differences to artificial & natural selection. The NGSS’ CrossCutting Concepts and Science & Engineering Practices are embedded throughout the lesson.

The main learning objectives are:

- Using a model (kidney beans) to explore the natural variations within a population.
- Measuring differences between individuals in a population (population of beans).
- Describing how genetic/phenotypic variation is a key part of biological evolution because it is a prerequisite for natural selection.
- Demonstrating in which ways genetic variation is advantageous to a population because it enables some individuals to adapt to the environment while maintaining the survival of the population.

The NGSS Performance Expectations covered are HS-LS4-2. & HS-LS4-4.

Type: Video/Audio/Animation

## Virtual Manipulatives

Evolution is the process by which modern organisms have descended from ancient ancestors. There are five processes that can lead to evolution within a population. These are Genetic drift, Gene flow, Mutation, Natural selection and Sexual selection. This tutorial will help the learners understand and visualize the way by which these processes affect evolution.

Type: Virtual Manipulative

This virtual lab provides an excellent resource to show how biotechnology can be incorporated into an actual situation. The student will be walked through the gel electrophoresis process and then apply the results to solve a crime.

Type: Virtual Manipulative

This virtual manipulative allows the user to explore scenarios of a loan repayment by manipulating the amount of the loan, interest rate, payment amount, frequency of payments, and length of the loan in years.

Type: Virtual Manipulative

This simulation allows the student to create a box plot and a histogram for the same set of data and toggle between the two displays. Maximum, minimum, median and mean are shown for the data set. The student can change the cell width to explore how the histogram is affected.

Type: Virtual Manipulative

This manipulative will help students in understanding scatter plots which are particularly useful when investigating whether there is a relationship between two variables. Students could develop a systematic plan for collecting and entering data into the scatter plot manipulative and set appropriate ranges for the *x* and *y* scales.

Type: Virtual Manipulative

In this activity, students adjust slider bars which adjust the coefficients and constants of a linear function and examine how their changes affect the graph. The equation of the line can be in slope-intercept form or standard form. This activity allows students to explore linear equations, slopes, and y-intercepts and their visual representation on a graph. This activity includes supplemental materials, including background information about the topics covered, a description of how to use the application, and exploration questions for use with the java applet.

Type: Virtual Manipulative

This resource provides linear functions in standard form and asks the user to graph it using intercepts on an interactive graph below the problem. Immediate feedback is provided, and for incorrect responses, each step of the solution is thoroughly modeled.

Type: Virtual Manipulative

The split brain experiments revealed that the right and the left hemisphere in the brain are good at different things. For instance, the right hemisphere is good at space perception tasks and music while the left is good at verbal and analytic tasks. This game guides students through some examples of the split-brain phenomenon and how the differences are understood.

Type: Virtual Manipulative

This virtual manipulative will help the students learn about enzyme-substrate docking. Students will observe that the shapes of these surfaces and electrostatic forces are the major factors that govern docking.

Type: Virtual Manipulative

The genes in DNA encode protein molecules. Expressing a gene means manufacturing its corresponding protein.Translation is the key process of making a protein from the genetic code expresses in the DNA. In translation, messenger RNA is read according to the genetic code, which relates the DNA sequence to the amino acid sequence in proteins. This virtual manipulative will allow the students to understand the process of translation. Students will also get a chance to observe, what happens when a new random mutation generates stop codons.

Type: Virtual Manipulative

Allows students access to a Cartesian Coordinate System where linear equations can be graphed and details of the line and the slope can be observed.

Type: Virtual Manipulative

How do strong and weak acids differ? Use lab tools on your computer to find out! Dip the paper or the probe into solution to measure the pH, or put in the electrodes to measure the conductivity. Then see how concentration and strength affect pH. Can a weak acid solution have the same pH as a strong acid solution.

Some of the topics to investigate:

- Given acids or bases at the same concentration, demonstrate understanding of acid and base strength by 1. Relating the strength of an acid or base to the extent to which it dissociates in water. 2. Identifying all the molecules and ions that are present in a given acid or base solution. 3. Comparing the relative concentrations of molecules and ions in weak versus strong acid (or base) solutions. 4. Describing the similarities and differences between strong acids and weak acids or strong bases and weak bases.
- Demonstrate understanding of solution concentrated by: 1. Describing the similarities and differences between concentrated and dilute solutions. 2. Comparing the concentrations of all molecules and ions in concentrated versus dilute solutions of a particular acid or base.
- Describe how common tools (pH meter, conductivity, pH paper) help identify whether a solution is an acid or base and strong or weak and concentrated or dilute.

Type: Virtual Manipulative

The lac operon is a set of genes which are responsible for the metabolism of lactose in some bacterial cells. Students will explore the effects of mutation within the lac operon by adding or removing genes from the DNA.

- Predicts the effects on lactose metabolism when the various genes and DNA control elements are mutated (added or removed).
- Predicts the effects on lactose metabolism when the concentration of lactose is changed.
- Explain the roles of Lacl, LacZ, and LacY in lactose regulation.

Type: Virtual Manipulative

In this activity, students use preset data or enter in their own data to be represented in a box plot. This activity allows students to explore single as well as side-by-side box plots of different data. This activity includes supplemental materials, including background information about the topics covered, a description of how to use the application, and exploration questions for use with the Java applet.

Type: Virtual Manipulative

Using this virtual manipulative, students are able to graph a function and a set of ordered pairs on the same coordinate plane. The constants, coefficients, and exponents can be adjusted using slider bars, so the student can explore the affect on the graph as the function parameters are changed. Students can also examine the deviation of the data from the function. This activity includes supplemental materials, including background information about the topics covered, a description of how to use the application, and exploration questions for use with the java applet.

Type: Virtual Manipulative

With this online tool, students adjust the standard deviation and sample size of a normal distribution to see how it will affect a histogram of that distribution. This activity allows students to explore the effect of changing the sample size in an experiment and the effect of changing the standard deviation of a normal distribution. Tabs at the top of the page provide access to supplemental materials, including background information about the topics covered, a description of how to use the application, and exploration questions for use with the java applet.

Type: Virtual Manipulative

In this online tool, students input a function to create a graph where the constants, coefficients, and exponents can be adjusted by slider bars. This tool allows students to explore graphs of functions and how adjusting the numbers in the function affect the graph. Using tabs at the top of the page you can also access supplemental materials, including background information about the topics covered, a description of how to use the application, and exploration questions for use with the java applet.

Type: Virtual Manipulative

This is an online graphing utility that can be used to create box plots, bubble graphs, scatterplots, histograms, and stem-and-leaf plots.

Type: Virtual Manipulative

Students can test the pH of several substances and visualize hydronium, hydroxide, and water molecules in solution by concentration or the number of molecules. Students can add water to a given substance to see the effects it will have on the pH of that substance; or they can create their own custom substance.

Type: Virtual Manipulative

With a mouse, students will drag data points (with their error bars) and watch the best-fit polynomial curve form instantly. Students can choose the type of fit: linear, quadratic, cubic, or quartic. Best fit or adjustable fit can be displayed.

Type: Virtual Manipulative

This interactive simulation investigates graphing linear and quadratic equations. Users are given the ability to define and change the coefficients and constants in order to observe resulting changes in the graph(s).

Type: Virtual Manipulative

This virtual manipulative histogram tool can aid in analyzing the distribution of a dataset. It has 6 preset datasets and a function to add your own data for analysis.

Type: Virtual Manipulative

In this activity, students can create and view a histogram using existing data sets or original data entered. Students can adjust the interval size using a slider bar, and they can also adjust the other scales on the graph. This activity allows students to explore histograms as a way to represent data as well as the concepts of mean, standard deviation, and scale. This activity includes supplemental materials, including background information about the topics covered, a description of how to use the application, and exploration questions for use with the java applet.

Type: Virtual Manipulative

Section:Grades PreK to 12 Education Courses >Grade Group:Grades 9 to 12 and Adult Education Courses >Subject:Science >SubSubject:Biological Sciences >