The Wolfman Syndrome

This clicker case uses congenital generalized hypertrichosis (CGH), a rare genetic disease, to teach students the basic principles of Mendelian inheritance.

Students watch a video clip from an ABC News interview that introduces them to Danny Gomez, a circus performer with the Mexican international Circus. Danny and several other family members of his family have a condition called hypertrichosis-excessive hair growth in areas of the body that is not predominately androgen dependent. In the process of meeting Danny and his family, students learn basic genetic concepts including DNA organization, karyotype analysis, dominance and recessive patterns of inheritance, sex linkage, and lyonization, as well as a brief introduction to the evolutionary idea of atavism.

Resource ID#: 31473 Type: Lesson Plan

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Open Resource Page

Direct Link: http://sciencecases.lib.buffalo.edu/cs/collection/detail.asp?case_id=480&id=480

General Information

Subject(s): Science

Grade Level(s): 9, 10, 11, 12

Intended Audience: Educators

Suggested Technology: Computer for Presenter, Computers for Students, Internet Connection, LCD Projector

Instructional Time: 2 Hour(s)

Resource supports reading in content area:Yes
Freely Available: Yes

Keywords: DNA, karyotype, patterns of inheritance, sex-linkage, lyonization

Instructional Component Type(s): Lesson Plan

Instructional Design Framework(s): Direct Instruction, Structured Inquiry (Level 2), Guided Inquiry (Level 3)

Resource Collection: FCR-STEMLearn Science - General

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